First sodium nitrite solution and hydrochloric acid solution are dropped at the same rate into the synthesis pipe, when the chlorine gas bubbles in the pipe,isoamyl alcohol is slowly dropped from the top of the pipe, that is in the pipeline synthetic crude. The reaction takes place in the reaction tube, in synthetic aqueous solution of sodium nitrite, isoamyl alcohol, hydrochloric acid, respectively, are put into the high slot. According to the actual production situation, it may have a different method of operation. ![]() It is derived from isoamyl alcohol and sodium nitrite. It can be used as an oxidizing agent, solvent. It is also used as hydrocyanic acid and its salts poisoning antidote.Vasodilators, for the treatment of angina pectoris, also it is used for cyanide poisoning it is used in synthesizing perfumes, drugs and diazo compounds. Isobutyl nitrite ester is a drug that is the the fastest short-acting nitrates vasodilator. It is used in synthesizing perfumes, drugs and diazo compounds. With volatility, it will break down in the case of light and air. It is soluble with alcohol, ether, it can not dissolve in water. Light yellow clear liquid having a boiling point of 99 ☌, the relative density is 0.871 (20/4 ℃), the refractive index is 1.3871, the flash point is 10 ℃. The above information is edited by the Chemicalbook of Tian Ye. For emergency use, sodium nitrite is intravenous injected until the symptoms improve. This product is administrated by inhalation, rapidly absorbed in the lungs, displays the effects after inhalation of 10 to 30 seconds, the role lasts for 3 to 5 minutes. Pharmacological effects are the same with sodium nitrite, isoamyl nitrite is also an oxidizing agent, hemoglobin is oxidized to be high iron (Fe3 +) hemoglobin combines with cyanide ions to form cyanide methemoglobin, eliminates blood free cyanide ions on cytochrome oxidase enzyme infringement, but also makes the cytochrome oxidase bound cyanide ion release, leading to the enzyme activity and tissue respiration function recovery, it should be used simultaneously with sodium thiosulfate to bind with cyanide methemoglobin to form non-toxic thiocyanate group (SCN-) and excreted, and thus play a role in the treatment of cyanide poisoning. ![]() Using in coronary occlusion and increased intracranial pressure is banned. Usinge for head trauma, brain hemorrhage, acute coronary thrombosis is banned. Due to excessive methemoglobin poisoning, symptoms include cyanosis, breathing difficulty and other symptoms of hypoxia, intravenous injection of 1% methylene blue is used for first aid, along with oxygen, and blood transfusions. Isoamyl nitrite owns severe reaction than nitroglycerin.Įxcessive use dosage can cause low blood pressure and heart rate, increase symptoms of angina, heart rate and blood pressure should be closely observed during intravenous drug using. Because it often causes severe headache, severe hypotension and tachycardia, it is now rarely used in clinical treatment of angina and biliary colic, gradually being replaced by other nitrates.Ĭommon adverse reactions are headache, facial flushing, hypotension and reflex tachycardia ect. ![]() Because of its rapid hydrolysis in the gastrointestinal tract, so this product is oral invalid, drugs used clinically are usually made on a volatile liquid pharmaceutical inhalants, rapidly absorbed in the lungs after inhalation, it can be effective less than half a minute, lasts for only 3 to 10 minutes, the anti-anginal effect nitroglycerin similar, but inhaled dose of this product is difficult to control, and the adverse reaction is large, which is its shortcomings. Isoamyl nitrite, also known as amyl nitrite, is the fastest onset, and the shortest duration of anti-anginal drugs, is a sub-short-acting nitrates vasodilator, its pharmacological effects is similar to nitroglycerin, it can directly relax vascular smooth muscle, especially for small vascular smooth muscle, make systemic vasodilation, reduce peripheral resistance, blood pressure, reduce venous return blood, reduce cardiac output, thereby reduce myocardial oxygen consumption, anti-angina and effectively stimulate sexual desire. In case of light and air it will break down. It is insoluble in water, can be mixed with alcohol, ether, chloroform or benzene arbitrary at any ratio. ![]() It volatiles at room temperature, and is easy to burn. Light yellow transparent liquid, ether-like smell with fruity.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |